Noncompetitive, Ca2 -independent inhibition of pyruvate dehydrogenase phosphatase by fluphenazine
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چکیده
منابع مشابه
Inhibition of pyruvate dehydrogenase complex by moniliformin.
The mechanism for the inhibition of pyruvate dehydrogenase complex from bovine heart by moniliformin was investigated. Thiamin pyrophosphate proved to be necessary for the inhibitory action of moniliformin. The inhibition reaction was shown to be time-dependent and to follow first-order and saturation kinetics. Pyruvate protected the pyruvate dehydrogenase complex against moniliformin inactivat...
متن کاملPhosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase.
The phosphorylation of sites additional to an inactivating site inhibits the formation of active pig heart pyruvate dehydrogenase complex from inactive pyruvate dehydrogenase phosphate complex by pig heart pyruvate dehydrogenase phosphate phosphatase.
متن کاملMechanism of Pyruvate Inhibition of Kidney Pyruvate Dehydrogenase, Kinase and Synergistic Inhibition by Pyruvate and ADP*
Pyruvate has been shown to both stimulate and inhibit kidney pyruvate dehydrogenase, (PDH,) kinase activity. The present study investigates the inhibitory effect of pyruvate under conditions in which the stimulatory effect is invariant. Inhibition of PDH, kinase activity by dichloroacetate, a pyruvate analog, is also characterized. Both pyruvate and dichloroacetate are uncompetitive, hyperbolic...
متن کاملRole of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase.
Bovine pyruvate dehydrogenase phosphatase (PDP) is a Mg2+-dependent and Ca2+-stimulated heterodimer that is a member of the protein phosphatase 2C family and is localized to mitochondria. Insight into the function of the regulatory subunit of PDP (PDPr) has been gained. It decreases the sensitivity of the catalytic subunit of PDP (PDPc) to Mg2+. The apparent Km of PDPc for Mg2+ is increased abo...
متن کاملIs there a role for pyruvate dehydrogenase-phosphatase in the re-activation of hepatic pyruvate dehydrogenase complex after re-feeding?
In starvation, inhibition of the pyruvate dehydrogenase complex (PDH) is associated with activation of PDH kinase secondary to increased fat oxidation through increased mitochondrial acetyl-CoA/CoA and N A D H / N A D + concentration ratios (for review, see Randle, 1986). However, acute inhibition of mitochondria1 fat oxidation by 2-tetradecylglycidate ( T D G ) does not lead to reactivation of...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 1999
ISSN: 1521-6543
DOI: 10.1080/15216549900202153